Arthritis affects dogs much like it does people, causing pain and stiffness in joints. But dogs don’t complain much, so you may not even notice the signs.

An important FDA-regulated clinical trial is underway to evaluate a proposed new injectable treatment for arthritis in dogs.

And if your dog has signs of reduced mobility (see Q1 below) but hasn’t been recently treated for arthritis, your dog may be eligible to participate.

The first step is to ask your veterinarian if your dog might be eligible. Then find out if there’s a clinical investigator (veterinarian) in your area.

Participation is free, and the study is important!

  • Exams, bloodwork, and x-rays (if needed) are provided to participating dogs and paid for by the study sponsor
  • You can keep copies of the diagnostic test results after the study
  • Your participation could lead to a new kind of drug to treat painful osteoarthritis in dogs
  1. How would I know if my dog has arthritis?

    You may notice changes in your dog’s behavior, such as:

    • Reluctance to exercise
    • Stiff after exercise
    • Reluctance to jump in the car or go up or down stairs
    • Licking or chewing the affected joints
  2. Any one of these behaviors can be an indication that your dog is in pain, and should be discussed with your veterinarian.

  3. I thought arthritis was a disease of older dogs?

    Even younger dogs can develop arthritis, particularly athletic dogs or dogs that have had a joint injury. Veterinary medicine is recognizing the early signs of arthritis in pets and seeking ways to slow the progression of the disease to help ensure pets can live long and active lives.

  4. What is a clinical trial?

    Just like new medications for people, new drugs for dogs must be tested for safety and effectiveness. Extensive safety studies of the test medication are already completed. This specific study is regulated by the US Food and Drug Administration (FDA) and will evaluate effectiveness and the duration of effectiveness of a potential new injectable treatment for arthritis in dogs.

  5. What are the benefits of participating in this clinical study?
    • No-cost diagnostic tests and evaluation: Participating dogs may receive the following study-related medical services: exams, bloodwork, and x-rays (if needed). All study-related medical services are provided at no cost.
    • No-cost treatment (or placebo): Your dog will either be given the test drug or a placebo; however, patients in the study are twice as likely to receive the test drug.
    • Your dog will be part of a study designed to bring a new drug to the US that is approved in other countries for the treatment of arthritis.
  6. How do I participate?

    Your veterinarian will help you schedule an appointment for a preliminary evaluation of your dog with the clinical investigator (a veterinarian) in your area. You can search for an investigator by zip code by clicking here.

  7. Are there any risks involved to my dog?

    As with any medical treatment, there are risks and benefits. The study investigator will cover these with you at the preliminary evaluation.

  8. Are there any costs involved?

    No. Costs for all tests and treatments required for the study are paid by the study’s sponsor.

  9. Is there any chance my dog would receive a placebo?

    Dogs will be randomly assigned to receive either the test medication or a placebo; however, twice as many dogs will receive the test medication as receive placebo. Neither you nor the study investigator (veterinarian) will know whether your dog is receiving the test medication or the placebo.

  10. What will be expected of me if I enroll my dog?

    You must be willing to take your dog to the study investigator’s hospital for scheduled visits once per week for up to nine weeks.

  11. Where are the appointments?

    Your veterinarian will give you the name, address, and phone number for the Study Investigator’s hospital.

  12. Can all dogs participate?

    Dogs may be considered for enrollment if they:

    • Have a medical history and exam consistent with osteoarthritis (x-rays taken within last 6 months, if available)
    • Have not participated in a clinical study for arthritis within the last 6 months
    • Have not had surgery of the affected joint within the past 6 months
    • Have not been given pain medications, steroids, or nonsteroidal anti-inflammatory drugs (NSAIDs) for osteoarthritis within the past 2 months
    • Have no other untreated, uncontrolled illness
    • Are not pregnant or believed to be pregnant
    • Meet other criteria which will be explained by the clinical investigator
 a study

If you have a dog that may qualify for this study, enter your zip code to search for investigator sites in your area.